-
Nortilidine is the
major active metabolite of tilidine. It is
formed from
tilidine by
demethylation in the liver. The
racemate has
opioid analgesic effects...
-
metabolite nortilidine and then to bisnortilidine. It is the (1S,2R)-isomer (dextilidine) that is
responsible for its
analgesic activity.
Nortilidine binds...
-
manner to
other opioid active metabolites such as O-desmethyltramadol and
nortilidine.
Bisnortilidine Dezocine Tapentadol 7-Hydroxymitragynine
Gillen C, Haurand...
- dichloromethane;
degrades upon
contact with light. Mu
opioid metabolite,
nortilidine. PO. No data. Moderate-severe pain. As per
other opioids.
Tramadol Comes...
- 7-Hydroxymitragynine List of
investigational analgesics Tapentadol Nortilidine O-AMKD TLR4
Tramadol Pharmacokinetics,
PharmGKB Sevcik J,
Nieber K, Driessen...
- ICI-204448 J-113397 JTC-801 LPK-26
Methopholine MT-45 NDMC NNC 63-0532
Nortilidine O-Desmethyltramadol
Prodilidine Profadol Ro64-6198 SB-612111 SC-17599...
-
Lufuradom Metofoline MT-45
Desmethylclozapine Nexeridine NNC 63-0532
Nortilidine O-Desmethyltramadol
Phenadone Phencyclidine Prodilidine Profadol Ro64-6198...
- list of
fentanyl analogues Dipyanone Etodesnitazene Methylketobemidone Nortilidine O-Desmethyltramadol
Piperidylthiambutene Propylketobemidone European...
-
Methoxyacetylfentanyl Metodesnitazene Metonitazene MT-45 N-Desmethyl-BDPC,
Norbromadol Nortilidine O-Desmethyltramadol, O-DSMT
Piperidylthiambutene Protonitazene...
- codeine)
Tilidine 1⁄10 100 mg 6% (parent drug), 99% (active metabolite)
nortilidine 3.3 (PO) & 4.9 IV,
bisnortilidine 5 (PO) & 6.9 (IV) 2.2:1 10-15 minutes...
