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Norpsilocin, also
known as 4-hydroxy-N-methyltryptamine (4-HO-NMT), is a
tryptamine alkaloid recently discovered in 2017 in the
psychedelic mushroom Psilocybe...
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converted into
psilocin to
produce psychoactive effects.
Besides psilocin,
norpsilocin, baeocystin, norbaeocystin, and
aeruginascin may also be present, which...
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Baeocystin is
thought to be a
prodrug of
norpsilocin,
analogously to how
psilocybin is a
prodrug of psilocin.
Norpsilocin is a
potent and
centrally penetrant...
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Surprisingly however, the compound,
similarly to baeocystin, norbaeocystin, and
norpsilocin, does not
produce the head-twitch response, a
behavioral proxy of psychedelic...
- (4-HO-NALT) is a
tryptamine derivative developed by
modification of
norpsilocin (4-HO-NMT). It
produces a head-twitch
response in mice
consistent with...
- is a
prodrug of
psilocin and
baeocystin is
thought to be a
prodrug of
norpsilocin. 4-HT is a
potent and
centrally penetrant serotonin 5-HT2A
receptor agonist...
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Plasma 4-HIAA
levels are also much
higher than
those of free psilocin.
Norpsilocin (4-HO-NMT),
formed from
psilocin via
demethylation mediated by the cytochrome...
-
Williamson SE,
Baumann MH,
Glatfelter GC. Psychedelic-like
Activity of
Norpsilocin Analogues. ACS Chem Neurosci. 2024 Jan 17;15(2):315-327. doi:10.1021/acschemneuro...
-
Tryptamines Found in
Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin,
Norpsilocin, and Aeruginascin".
Journal of
Natural Products: 461–467. doi:10.1021/acs...
- effects), hypolocomotion, or hypothermia, in
contrast to
psilocin and
norpsilocin, but
similarly to aeruginascin. A
synthetic prodrug of 4-HO-TMT, 4-AcO-TMT...
