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Norpethidine (normeperidine,
pethidine intermediate B) is a 4-phenylpiperidine
derivative that is both a
precursor to, and the
toxic metabolite of, pethidine...
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neurotoxicity of its metabolite,
norpethidine, it is more
toxic than
other opioids—especially
during long-term use. The
norpethidine metabolite was
found to have...
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Diphenoxylate is made by
combining a
precursor of
normethadone with
norpethidine.
Loperamide (Imodium) and
bezitramide are analogs. Like loperamide, it...
- with this syndrome.
Pethidine is
avoided due to the
toxic metabolite norpethidine because of the high
amounts needed to
achieve pain relief. Most reported...
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Methadone intermediate Moramide intermediate Pethidine intermediate A
Norpethidine (Pethidine
intermediate B)
Pethidinic acid (Pethidine
intermediate C)...
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significantly greater in
vitro potency compared to desmethylprodine.
Norpethidine PEPAP US 2765314,
Schmidle CJ,
Mansfield RC, "Preparation of Esters"...
-
situation significant adverse effects from the
pethidine metabolite norpethidine may occur.
Magnesium sulfate (epsom salts) has been
proposed as a treatment...
- of
isonipecotic acid, like pethidine, and is
metabolized in part to
norpethidine. Its
potency range is due to
method of ingestion.
figure 20–80 times...
- Pethidine (meperidine)
Pethidine intermediate A
Pethidine intermediate B (
norpethidine)
Pethidine intermediate C (pethidinic acid)
Pheneridine Phenoperidine...
- MT-45
opioid 4-Phenylpiperidine-4-carboxylic acid
ethyl ester Norpethidine opioid (see notes) 1971
Commonly used in the
production of Pethidine...
