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Norpethidine (
normeperidine,
pethidine intermediate B) is a 4-phenylpiperidine
derivative that is both a
precursor to, and the
toxic metabolite of, pethidine...
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metabolized to the
active metabolites of
normeperidine,
normepiridinic acid, and
medperidinic acid.
Normeperidine may ac****ulate to
toxic levels in patients...
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attributed to ac****ulation in
plasma of the
metabolite norpethidine (
normeperidine).
Fatalities have
occurred following either oral or
intravenous pethidine...
- half-life and
repeated doses can lead to ac****ulation of the
metabolite normeperidine,
which causes neuromuscular side
effects and, rarely, seizures. Acute...
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which is
controlled under UN drug conventions. The key intermediate,
normeperidine, is
obtained by a
scheme closely akin to the
parent molecule. Thus,...
-
determination of
pethidine (meperidine), phenoperidine, and
norpethidine (
normeperidine),
their common metabolite, by gas
chromatography with
selective nitrogen...
