- A
nonsynonymous substitution is a
nucleotide mutation that
alters the
amino acid
sequence of a protein.
Nonsynonymous substitutions differ from synonymous...
- protein-coding genes. It is
calculated as the
ratio of the
number of
nonsynonymous substitutions per non-synonymous site (Ka), in a
given period of time...
- or deleterious. The two
types of
sites can be
either synonymous or
nonsynonymous within a protein-coding region. In a protein-coding
sequence of DNA...
-
results in a
codon that
codes for a
different amino acid. It is a type of
nonsynonymous substitution.
Missense mutations change amino acids,
which in turn alter...
-
Fisher SA,
Franke A,
Hampe J,
Onnie CM,
Soars D, et al. (May 2007). "A
nonsynonymous SNP in ATG16L1
predisposes to
ileal Crohn's
disease and is independent...
- to
point mutation in the
corresponding DNA sequence. It is
caused by
nonsynonymous missense mutation which changes the
codon sequence to code
other amino...
- two types:
synonymous SNPs and
nonsynonymous SNPs.
Synonymous SNPs do not
affect the
protein sequence,
while nonsynonymous SNPs
change the
amino acid sequence...
-
protein coding region of a gene may be
classified as
synonymous or
nonsynonymous substitutions, the
latter of
which in turn can be
divided into missense...
- (dS) and
nonsynonymous substitutions per
nonsynonymous site (dN) must be
account for,
along with the
variances of the
synonymous and
nonsynonymous substitutions...
- M (June 2003). "Implications of
natural selection in
shaping 99.4%
nonsynonymous DNA
identity between humans and chimpanzees:
enlarging genus Homo"....
