-
Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the
endogenous ligand for the
nociceptin receptor (NOP, ORL-1).
Nociceptin acts as a...
- The
nociceptin opioid peptide receptor (NOP), also
known as the
nociceptin/orphanin FQ (N/OFQ)
receptor or kappa-type 3
opioid receptor, is a
protein that...
- of the μ-, δ-, and κ-opioid receptors. It has a weak
affinity for the
nociceptin receptor.
Etorphine has an LD50 of 3 μg in humans. In Hong Kong, etorphine...
-
endogenous opioids are dynorphins, enkephalins, endorphins,
endomorphins and
nociceptin. The
opioid receptors are ~40%
identical to
somatostatin receptors (SSTRs)...
- spioxatrine, and L008716. The
pharmacology of R6890 is
described as a
nociceptin receptor (NOP) agonist,
although R6890
retains significant activity at...
- bind to
kappa receptors),
endorphins (mu receptors), endomorphins, and
nociceptin-orphanin FQ. The
opioid receptors are ~40%
identical to
somatostatin receptors...
-
Norbinaltorphimine is a
selective KOR
antagonist J-113,397 is a
selective nociceptin receptor (NOP)
antagonist Other selective antagonists are also known,...
- of
action involved. One
major pathway being through stimulation of the
nociceptin receptor, and
blocking this
receptor may
therefore be a
means of preventing...
-
Opioid receptor modulators μ-opioid (MOR) δ-opioid (DOR) κ-opioid (KOR)
Nociceptin (NOP)
Others Enkephalinase inhibitors:
Amastatin BL-2401
Candoxatril D-Phenylalanine...
- (Ki = 18 nM; EC50 = 110 nM; IA = 105%), and as a
partial agonist of the
nociceptin receptor (Ki = 0.9 nM; EC50 = 13.0 nM;
IATooltip intrinsic activity =...
