-
Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the
endogenous ligand for the
nociceptin receptor (NOP, ORL-1).
Nociceptin acts as a...
- The
nociceptin opioid peptide receptor (NOP), also
known as the
nociceptin/orphanin FQ (N/OFQ)
receptor or kappa-type 3
opioid receptor, is a
protein that...
-
endogenous opioids are dynorphins, enkephalins, endorphins,
endomorphins and
nociceptin. The
opioid receptors are ~40%
identical to
somatostatin receptors (SSTRs)...
- of the μ-, δ-, and κ-opioid receptors. It has a weak
affinity for the
nociceptin receptor.
Etorphine has an LD50 of 3 μg in humans. In Hong Kong, etorphine...
- of
action involved. One
major pathway being through stimulation of the
nociceptin receptor, and
blocking this
receptor may
therefore be a
means of preventing...
-
effectively does
nothing at all 3-Nitrooxypropanol, an
enzyme inhibitor Nociceptin receptor, a
neurotransmitter receptor in the
opioid receptor family Croatian...
-
Norbinaltorphimine is a
selective KOR
antagonist J-113,397 is a
selective nociceptin receptor (NOP)
antagonist Other selective antagonists are also known,...
- bind to
kappa receptors),
endorphins (mu receptors), endomorphins, and
nociceptin/orphanin FQ. The
opioid receptors are ~40%
identical to
somatostatin receptors...
-
Agonists (Arg14,Lys15)
Nociceptin ((pF)Phe4)
Nociceptin(1-13)NH2 (Phe1Ψ(CH2-NH)Gly2)
Nociceptin(1-13)NH2 Ac-RYYRWK-NH2 Ac-RYYRIK-NH2 BU08070 Buprenorphine...
- the
first compound found to be a
highly selective antagonist for the
nociceptin receptor, also
known as the ORL-1 receptor. It is
several hundred times...
