- In
organic chemistry, a
nitrone is a
functional group consisting of an N-oxide of an imine. The
general structure is R1R2C=N+(−O−)(−R3),
where R3 is not...
- The
nitrone-olefin (3+2)
cycloaddition reaction is the
combination of a
nitrone with an
alkene or
alkyne to
generate an
isoxazoline or
isoxazolidine via...
-
azides and
cyclooctynes (also
termed copper-free
click chemistry),
between nitrones and cyclooctynes, oxime/hydrazone
formation from
aldehydes and ketones...
- of the
nitrone dipole, and
acyclic and
endocyclic nitrones are all tolerated. This
large allowance provides a lot of
flexibility for
nitrone handle or...
- reaction. The ****sgen
cycloaddition reaction is a (2+3)cycloaddition. The
Nitrone-olefin
cycloaddition is a (3+2)cycloaddition.
Cheletropic reactions are...
- with
nitro compounds to give a
nitrone; but a
Grignard reagent with an α
hydrogen will then add
again to the
nitrone to give a
hydroxylamine salt. The...
-
azides and
cyclooctynes (also
termed copper-free
click chemistry),
between nitrones and cyclooctynes, oxime/hydrazone
formation from
aldehydes and ketones...
-
sodium (Cerovive, OKN-007, NXY-059, HPN-07) is a free
radical trapping nitrone-based
antioxidant compound that has been
under development for several...
- The
rearrangement has also been
successfully performed on
haloimines and
nitrones.
Cyclic oximes and
haloimines yield lactams. The
Beckmann rearrangement...
- spine. A 2025
phase II
study published found that
tetramethylpyrazine nitrone is safe for
patients with ALS, but it did not show a
significant advantage...
