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Nicastrin, also
known as NCSTN, is a
protein that in
humans is
encoded by the
NCSTN gene.
Nicastrin (abbreviated NCT) is a
protein that is part of the...
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secretase complex consists of four
individual proteins: PSEN1 (presenilin-1),
nicastrin, APH-1 (anterior pharynx-defective 1), and PEN-2 (presenilin enhancer...
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Caenorhabditis elegans as a
regulator of the cell-surface
localization of
nicastrin in the
Notch signaling pathway. APH-1
homologs in
other organisms, including...
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interact with: BCL2-like 1, CAPN1, CIB1, Calsenilin, FHL2, FLNB, KCNIP4,
Nicastrin, and UBQLN1. GRCh38:
Ensembl release 89: ENSG00000143801 – Ensembl, May...
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Presenilins 1 and 2 are the
enzymatic centers of this
complex along with
nicastrin, Aph1, and PEN-2. Alpha-secretase
cleavage of APP,
which precludes the...
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Dakota Nuclear Compton Telescope, a balloon-borne gamma-ray
detector Nicastrin, a
protein component of the
gamma secretase enzyme complex Nocturnal ****oral...
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protein (APP). The
gamma secretase complex consists of PEN-2, APH-1,
nicastrin, and the
catalytic subunit presenilin. PEN-2 is a 101-amino acid integral...
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complex imaged using cryo-electron microscopy. The
structure contains nicastrin (red), presenilin-1 (orange), PEN-2 (blue), and APH-1 (green). This is...
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mature and
immature forms of
presenilins and
nicastrin and may play a role in
maturation of presenilin.
nicastrin complexes". J. Biol. Chem. 278 (9): 7374–80...
- disease.
These include the
discovery of the
presenilins (PSEN1 and PSEN2),
Nicastrin, TREM2,
Apolipoprotein E and SORL1 genes.
Presenilin mutations are the...
