-
Neprilysin (/ˌnɛprɪˈlaɪsɪn/; also
known as
membrane metallo-endopeptidase (MME),
neutral endopeptidase (NEP),
cluster of
differentiation 10 (CD10) and...
- fixed-dose
combination medication for use in
heart failure. It
consists of the
neprilysin inhibitor sacubitril and the
angiotensin receptor blocker valsartan. The...
- (LBQ657) by de-ethylation via esterases.
Sacubitrilat inhibits the
enzyme neprilysin,
which is
responsible for the
degradation of
atrial and
brain natriuretic...
- at pH 2.
Glutamyl endopeptidase - cuts
after Glu.
Works best at pH 8.
Neprilysin "endopeptidase". Merriam-Webster.
Archived from the
original on 21 December...
- (ACE) inhibitors,
angiotensin II
antagonists (ARBs), and Angiotensin-
Neprilysin Inhibitor LCZ969.: 120 The
angioedema appears to be dose
dependent as...
-
experimental antihypertensive agent that was
never marketed. It
inhibits both
neprilysin (neutral endopeptidase, NEP) and angiotensin-converting
enzyme (ACE)....
-
nesiritide in
patients with
acute decompensated heart failure.
Blockade of
neprilysin, a
protease known to
degrade members of the
natriuretic peptide family...
-
different kininases: angiotensin-converting
enzyme (ACE,
kininase II),
neprilysin, NEP2,
aminopeptidase P (APP),
carboxypeptidase N (CPN,
kininase I), Carboxypeptidase...
- Gong J,
Lefkowitz MP,
Rizkala AR, et al. (September 2014). "Angiotensin-
neprilysin inhibition versus enalapril in
heart failure". The New
England Journal...
- The
polypeptide Ang I can be
converted into Ang (1-7) by the
actions of
neprilysin (NEP) and
thimet oligopeptidase (TOP) enzymes. Also, Ang II can be hydrolyzed...
