- is the
organosilicon compound with the
formula NaN(Si(CH3)3)2. This species,
usually called NaHMDS (sodium hexamethyldisilazide), is a
strong base used...
- Li as in
Lithium bis(trimethylsilyl)amide (Li
HMDS) M =
Na as in
Sodium bis(trimethylsilyl)amide (
NaHMDS) M = K as in Pot****ium bis(trimethylsilyl)amide...
- Silicon-based amides, such as
sodium and pot****ium bis(trimethylsilyl)amide (
NaHMDS and KHMDS, respectively)
Lithium tetramethylpiperidide (LiTMP or harpoon...
- by the
related reagents sodium hydride,
sodium bis(trimethylsilyl)amide (
NaHMDS), and
lithium diisopropylamide (LDA).
Rearrangement with orthodeprotonation...
-
sodium and pot****ium
hexamethyldisilazide (Li
HMDS,
NaHMDS, KHDMS,
where HDMS = N(SiMe3)2), or
sodium hydride (
NaH) are also
commonly used. For stabilized...
-
procedure is to use a
stoichiometric amount of a
strong base such as LDA or
NaHMDS. In this case,
enolate formation is irreversible, and the
aldol product...
-
procedure is to use a
stoichiometric amount of a
strong base such as LDA or
NaHMDS. In this case,
enolate formation is irreversible, and the
aldol product...
-
LiHMDS and
other similar derivatives:
sodium bis(trimethylsilyl)amide (
NaHMDS) and pot****ium bis(trimethylsilyl)amide (KHMDS) are used as a non-nucleophilic...
- hours. The
solution was
cooled to 0°C,
building block B10 and a
solution of
NaHMDS in THF were added. Then the
solution was
stirred for 20
hours at 20°C and...
- bis(trimethylsilyl)amides via a salt
metathesis reaction: MCln + n
Na(
hmds) → M(
hmds)n + n
NaCl
Alkali metal chloride formed as a by-product
typically precipitates...
