- NAD+ glycohydrolase.
Other names in
common use
include NAD+ nucleosidase,
NADase, DPNase, DPN hydrolase, NAD hydrolase,
diphosphopyridine nucleosidase, nicotinamide...
- Vacor-mononucleotide (VMN) by
NAMPT and VMN's
subsequent activation of the
NADase SARM1. Vogel, R. P. (1982). "Poisoning with
Vacor Rodenticide". Archives...
- NAD+
cleavage activity, such as in SARM1. In the case of SARM1, the TIR
NADase activity leads to the
production of Nam, ADPR and
cADPR and the activation...
- Toll/Interleukin receptor-1 (TIR) family. SARM1's TIR
domain has
intrinsic NADase enzymatic activity that is
highly conserved from archaea, plants, nematode...
- from NAD+. CD38 is
thought to be a
major regulator of NAD+ levels, its
NADase activity is much
higher than its
function as an ADP-rybosyl-cyclase: for...
-
Warner GM, Tarragó MG,
Peclat TR,
Tchkonia T, et al. (May 2019). "The
NADase CD38 is
induced by
factors secreted from
senescent cells providing a potential...
-
tumor cells and
blocks CD38-positive T-regulatory cells. Furthermore, the
NADase activity of CD38 is
adjusted by isatuximab,
similarly to
other CD38 antibodies...
-
induce cachexia, or loss of weight,
within hosts. Cord
factor also
increases NADase activity in the host, and thus it
lowers NAD;
enzymes that
require NAD decrease...
-
arginine or
simple guanidino compounds, the
toxin mediated NAD+
nucleosidase (
NADase)
activity proceeds using water as a nucleophile. The B
subunits form a five-membered...
