- Bone
marrow suppression also
known as
myelotoxicity or
myelosuppression, is the
decrease in
production of
cells responsible for
providing immunity (leukocytes)...
- follicles. This
results in the most
common side-effects of chemotherapy:
myelosuppression (decreased
production of
blood cells,
hence that also immunosuppression)...
-
myelosuppression. ++
means 30-70% of
patients exhibit significant myelosuppression. +
means 10-30% of
patients exhibit significant myelosuppression....
-
lymphocyte proliferation via
conversion to
mercaptopurine PO, IV D (Au)
Myelosuppression and
rarely malignancy, hepatitis, infection,
hepatic sinusoidal obstruction...
- Hair loss
Dermatitis Indigestion Shortness of
breath Eye
irritation Myelosuppression Notes on
adverse effects: Includes: anaemia, lymphopenia, neutropenia...
-
Myelodysplastic syndromes,
acute myeloid leukaemia and
chronic myeloid leukaemia Myelosuppression,
kidney failure (uncommon/rare),
renal tubular acidosis and hypokalaemia...
- omacetaxine. By frequency: Very
common (>10% frequency):
Diarrhea Myelosuppression†
Injection site
reactions Nausea Fatigue Fever Muscle weakness Joint...
-
substantially more
powerful and have
fewer side effects —
except for
greater myelosuppression. In 2005,
Celgene received FDA
approval for
lenalidomide (Revlimid)...
- part of SCLC
treatment frequently experience chemotherapy-induced
myelosuppression. In
three randomized, placebo-controlled SCLC trials, trilaciclib,...
-
failure 2%
Neuroendocrine hormonal crisis Hypotension 1%
Bronchospasm Myelosuppression 1%
Lymphopenia 44%
Anemia Thrombocytopenia Leukopenia Neutropenia Cardiac...
