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Monobodies are
synthetic binding proteins constructed using a
fibronectin type III
domain (FN3) as a
molecular scaffold. Specifically, this
class of binding...
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Smith Cisco S****
Dusty Patches Jodi
Kaina Luke
Titus Lynyn Marcus Drake Monobody NNAMDÏ
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Gabriel Sen
Morimoto Sonny Falls This Is Lorelei...
- The TICI
components may be
integrated into a
single case, the so-called
monobody design, or the
various components may be
attached to one
another by connectors...
-
Fibronectin type I
domain Fibronectin type II
domain Fibronectin type III
domain Monobody, an
engineered antibody mimetic based on the
structure of the fibronectin...
- tumors. It is a
genetically engineered peptide derivative based on the
monobody technology, and is
being developed by Adnexus. The drug has
entered Phase...
- fibronectin).
Monobodies feature either diversified loops or
diversified strands of a flat beta-sheet surface,
which serve as
interaction epitopes.
Monobody binders...
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Intracellular Intrabody Antibody mimetics Affibody molecule Affilin Affimer Affitin Alphabody Anticalin Avimer DARPin Kunitz domain peptide Monobody nanoCLAMP...
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Vesalius Biocapital, and Vinnof.
Affibody Affimer Affitin Anticalin DARPin Monobody Desmet, J.; Verstraete, K.; Bloch, Y.; Lorent, E.; Wen, Y.; Devreese, B...
- Drug
Discov Dev. 9 (2): 261–8. PMID 16566296.
Koide A,
Koide S (2007). "
Monobodies:
antibody mimics based on the
scaffold of the
fibronectin type III domain"...
-
Wojcik JB, Li NS,
Piccirilli JA, Chen Y,
Koide S (2011). "Isoform-specific
monobody inhibitors of
small ubiquitin-related
modifiers engineered using structure-guided...
