- to the
large importance of the
skeleton in survival. Few deviations,
misregulations, and
mutations are
found in
organisms because they are
often detrimental...
- histones, and
chromatin remodelling).
Ageing and
disease are
related to a
misregulation of gene
expression through impaired methylation patterns, from hypomethylation...
- in epithelia,
positive T-cell selection, and CD8 T-cell activation.
Misregulation of
CaMKII is
linked to Alzheimer's disease,
Angelman syndrome, and heart...
- Lee TI,
Young RA (March 2013). "Transcriptional
regulation and its
misregulation in disease". Cell. 152 (6): 1237–1251. doi:10.1016/j.cell.2013.02.014...
-
ubiquitylation functions to
tightly regulate the
cellular level of cyclins, its
misregulation is
expected to have
severe impacts.
First evidence of the importance...
- gene silencing. The
disorganization in
telomeres may have led to the
misregulation of ****ual development. Moreover, the
discovery of
specific transcription...
-
mislocalisation of heterochromatin,
which normally lie in
close proximity, or with, the
nuclear matrix,
nuclear blebbing and
misregulation of gene expression....
-
including cyclins, CDKs,
checkpoint regulators, and DNA
repair proteins.
Misregulation of the E2F
family is
often found in
cancer cases,
providing evidence...
- such as anti-centromere antibodies. It has been
known that
centromere misregulation contributes to mis-segregation of chromosomes,
which is
strongly related...
-
signalling in
pathological processes.
Cancerous disease often involves misregulation of the BMP
signalling system.
Absence of BMP
signalling is, for instance...
