- in nature. Such
designs include: Pincer-1 β-hairpin
peptides β-sheet
miniproteins Multi-stranded β-sheet
peptides Some
methodologies attempt to incorporate...
-
Diversity and
Therapeutic Potential of
Natural and
Engineered Cystine Knot
Miniproteins.”
Current Opinion in Pharmacology, vol. 9, no. 5, 2009, pp. 608–614....
- In 2013,
Verdine received a
research grant to
study cell-penetrating
miniproteins in
order to
target cancer cells. His work has led to the FDA approval...
- Cao L, Ying B,
Winkler ES,
Johnson M, et al. (July 2021). "Ultrapotent
miniproteins targeting the SARS-CoV-2 receptor-binding
domain protect against infection...
- J.; Chiche,
Laurent (2008). "Structure and
folding of disulfide-rich
miniproteins:
Insights from
molecular dynamics simulations and MM-PBSA free energy...
-
platform designed to
generate high-affinity
therapeutic antibodies and
miniprotein binders for
specific protein targets from scratch.
TenAces Biosciences...
- (2016-08-09). "Com****tional
investigation of cold
denaturation in the Trp-cage
miniprotein".
Proceedings of the
National Academy of Sciences. 113 (32): 8991–8996...
- the
phenotypic hallmarks of cancer. The
recombinantly produced Omomyc miniprotein has been
developed as a drug (OMO-103) and is
currently in
clinical trials...
- "Heterogeneous-backbone
foldamer mimics of a com****tionally designed, disulfide-rich
miniprotein". ChemBioChem. 20 (4): 103–110. doi:10.1002/cbic.201800558. PMC 239472...
-
using E. coli,
resulting in
recombinant CssII.
CssII is a
single chain miniprotein,
consisting of 66
amino acids: Lys-Glu-Gly-Tyr-Leu-Val-Ser-Lys-Ser-T...
