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Macrophage inducible Ca2+-dependent
lectin receptor, (abbreviated to
Mincle), is a
member of the C-type
lectin superfamily encoded by the gene CLEC4E....
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Mincle Mountain is a
summit in the U.S.
state of Georgia. The
elevation is 1,870 feet (570 m). A
variant name is "Mincie Mountain". The name is a corruption...
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phagocytes are targeted. For example,
mincle has been
shown to be
targeted by L. major.
Interaction between mincle and a
protein released by the parasite...
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evidence that cord
factor is
recognized by the
Mincle receptor,
which is
found on macrophages. An
activated Mincle receptor leads to a
pathway that ultimately...
- TLR2, TLR4 HMGB1 TLR2, TLR4, RAGE HMGN1 TLR4 IL-1α IL-1R IL-33 ST2 SAP130
Mincle DNA TLR9, AIM2 RNA TLR3, TLR7, TLR8, RIG-I, MDA5
Mitochondria mtDNA TLR9...
- TLR-dependent signaling. TLR-independent
signaling such as
Dectin 1, and
Dectin 2 –
mincle signaling lead to MAP
kinase and NFkB activation.
Membrane receptor CLRs...
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adaptive immune system myelocyte immune system C-type
lectin receptors (CLR) (Dectin 1,
Mincle) CARD9/BCL10/MALT1
complex → NF-κB
innate immune system...
- Miller, G. The
necrosome promotes pancreatic oncogenesis via CXCL1 and
Mincle-induced
immune suppression. (2016) Nature. 532(7598):245-9. DOI: 10.1038/nature17403...
- synthesis, and autophagy.
Crystals can also
directly activate inflammation via
Mincle receptors,
calcium and pot****ium signalling, calpains,
cathepsin beta, proteases...
- dectin-2
cluster is
composed of
genes encoding dectin-2, DCIR, DCAR, BDCA-2,
Mincle and Clecsf8,
which are the
members of the
group II C-type
lectin family...
