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Microcephalin (MCPH1) is a gene that is
expressed during fetal brain development.
Certain mutations in MCPH1, when homozygous,
cause primary microcephaly—a...
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Neanderthal relatives - in this case,
microcephalin, an
adaptive allele ****ociated with
brain development.
Microcephalin (MCPH1)
regulates brain size, and...
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genes ASPM (abnormal spindle-like
microcephaly ****ociated) and MCHP1 (
microcephalin-1) and
their ****ociation with the
human brain. In this
study researchers...
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after microcephalin (MCPH1),
based on
their role in
brain size and
primary microcephaly syndromes when mutated. In
addition to
microcephalin,
these include...
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suggested that a
group of
alleles collectively known as
haplogroup D of
microcephalin, a
critical regulatory gene for
brain volume,
originated from an archaic...
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capacity in humans. They
showed that two
brain size genes, ASPM and
Microcephalin (MCPH1),
whose null
mutations lead to
microcephaly (small head due to...
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control the size of the
human brain as it develops.
These genes are
Microcephalin (MCPH1) and
Abnormal Spindle-like
Microcephaly (ASPM). The researchers...
- and animals,
including humans, in
which it may have
introduced the
microcephalin D allele. It has been
proposed that, historically,
introgression with...
- po****tion,
suggesting inheritance from Neanderthals. In the case of the
Microcephalin D allele,
evidence for
rapid recent expansion indicated introgression...
-
studies reviewed, the
authors suggest a
mediating role of ASPM and
microcephalin genes in the
relationship between volumes of gray and
white matter of...
