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Mexiletine (INN) (sold
under the
brand names Mexitil and Namuscla) is a
medication used to
treat abnormal heart rhythms,
chronic pain, and some causes...
- CYP1A2
inhibitors (such as zileuton,
certain antiarrhythmics (amiodarone,
mexiletine, propafenone, verapamil), cimetidine, famotidine, aciclovir, ticlopidine...
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mexiletine also
shortens the QT
interval in
other forms of long QT
syndrome including LQT1, LQT2 and LQT8. As the
predominant action of
mexiletine is...
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Disopyramide Dronedarone Encainide Flecainide Lidocaine Lorajmine Lorcainide Mexiletine Moricizine Pilsicainide Prajmaline Procainamide Propafenone Quinidine...
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Disopyramide Dronedarone Encainide Flecainide Lidocaine Lorajmine Lorcainide Mexiletine Moricizine Pilsicainide Prajmaline Procainamide Propafenone Quinidine...
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mechanical allodynia –
compounds targeting different ion channels;
opioids Mexiletine Lidocaine (IV/topical)
Tramadol Morphine (IV)
Alfentanil (IV) Ketamine...
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Carbamazepine Lacosamide Local anesthetics (e.g., cocaine, lidocaine)
Mexiletine Nefopam Tricyclic antidepressants (e.g., amitriptyline#) Nav1.7/1.8-selective:...
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Disopyramide Dronedarone Encainide Flecainide Lidocaine Lorajmine Lorcainide Mexiletine Moricizine Pilsicainide Prajmaline Procainamide Propafenone Quinidine...
- with
antiarrhythmics if
hypokalemia occurs; the
effects of
lidocaine and
mexiletine are antagonized. Antibacterials:
increased risk of
ototoxicity with aminoglycosides...
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Carbamazepine Lacosamide Local anesthetics (e.g., cocaine, lidocaine)
Mexiletine Nefopam Tricyclic antidepressants (e.g., amitriptyline#) Nav1.7/1.8-selective:...
