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Mevalonic acid (MVA) is a key
organic compound in biochemistry; the name is a
contraction of dihydroxymethylvalerolactone. The
carboxylate anion of mevalonic...
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reduced or
deficient activity of this enzyme.
Because of this deficiency,
mevalonic acid can
build up in the body, with high
levels found in the urine. The...
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diseases affect the
mevalonate pathway:
Mevalonate Kinase Deficiency Mevalonic Aciduria Hyperimmunoglobulinemia D
Syndrome (HIDS). Plants, most bacteria...
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fungi possess a
biosynthetic pathway for
producing terpenes that uses
mevalonic acid and
pyrophosphate as
chemical building blocks.
Plants and some other...
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cholesterol and
other isoprenoids.
HMGCR catalyzes the
conversion of HMG-CoA to
mevalonic acid, a
necessary step in the
biosynthesis of cholesterol.
Normally in...
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researching the
biosynthesis of
cholesterol in the
early 1950s. In 1956,
mevalonic acid was
isolated from a
yeast extract by Karl Folkers, Carl Hoffman,...
- β-methylbutyryl-CoA (HMB-CoA). HMG-CoA
reductase catalyzes the
conversion of HMG-CoA to
mevalonic acid, a
necessary step in the
biosynthesis of cholesterol. Mevalonate...
- acid
tryptophan with
dimethylallyl diphosphate (isoprene
derived from 3R-
mevalonic acid)
giving 4-dimethylallyl-L-tryptophan
which is N-methylated with...
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between DMAPP and IPP. In the
mevalonate pathway,
DMAPP is
synthesised from
mevalonic acid. In contrast,
DMAPP is
synthesised from
HMBPP in the MEP pathway...
- phytoecdysteroids. Plants, but not animals,
synthesize phytoecdysteroids from
mevalonic acid in the
mevalonate pathway of the
plant cell
using acetyl-CoA as a...
