-
Methylenetetrahydrofolate reductase (MTHFR) is the rate-limiting
enzyme in the
methyl cycle, and it is
encoded by the
MTHFR gene. Methylenetetrahydrofolate...
- 5,10-
Methylenetetrahydrofolate (N5,N10-
Methylenetetrahydrofolate; 5,10-CH2-THF) is
cofactor in
several biochemical reactions. It
exists in
nature as the...
-
Levomefolic acid is
generated by
methylenetetrahydrofolate reductase (MTHFR) from 5,10-
methylenetetrahydrofolate (MTHF) and used to
recycle homocysteine...
-
Methylenetetrahydrofolate reductase deficiency is the most
common genetic cause of
elevated serum levels of
homocysteine (hyperhomocysteinemia). It is...
- step of the SAM cycle,
MTHFR (
methylenetetrahydrofolate reductase)
irreversibly reduces 5,10-
methylenetetrahydrofolate to 5-methyltetrahydrofolate. A...
- and pyridoxal. A
second enzyme,
methylenetetrahydrofolate dehydrogenase (MTHFD2)
oxidizes 5,10-
methylenetetrahydrofolate to an
iminium cation which in turn...
- (CH=) groups. It is
produced from 5,10-
methylenetetrahydrofolate by
either a NAD+
dependent methylenetetrahydrofolate dehydrogenase, or a NADP+ dependent...
-
alkaloid with antiviral,
antibacterial and
antifungal effects 5,10-
Methylenetetrahydrofolate, an
intermediate in one-carbon
metabolism Hexahydro-1,3,5-triazine...
-
conversions of L-serine to
glycine and
tetrahydrofolate (THF) to 5,10-
methylenetetrahydrofolate (5,10-CH2-THF). This
reaction provides the
largest part of the...
-
following reaction is
catalyzed by
thymidylate synthase: 5,10-
methylenetetrahydrofolate + dUMP ⇌ {\displaystyle \rightleftharpoons }
dihydrofolate + dTMP...
