-
slowly (poor
metabolizers). If a drug is
metabolized too quickly, it may
decrease the drug's
efficacy while if the drug is
metabolized too slowly, toxicity...
-
atomoxetine is
metabolized by CYP2D6,
exposure may be
increased 10-fold in CYP2D6 poor
metabolizers.
Among CYP2D6
extensive metabolizers, the half-life...
-
extensive metabolizers;
patients with
these metabolizer types may have an
increased probability of
experiencing side effects.
Ultrarapid metabolizers break...
- and
intermediate metabolizers have
reduced metabolism of the drug as
compared to
extensive metabolizers;
patients with
these metabolizer types may have...
-
fatty acids to
replace glucose in
tissues such as the
brain that
cannot metabolize fatty acids. In
other organisms such as
plants and bacteria, this metabolic...
- and
intermediate metabolizers have
reduced metabolism of the drug as
compared to
extensive metabolizers;
patients with
these metabolizer types may have...
- to a 27-hour half-life in
normal metabolizers).
Adverse effects were
reported at
similar rates in poor
metabolizers,
suggesting that it is not clinically...
-
processes are
often facilitated by
enzymes such as drug
transporters or drug
metabolizing enzymes (discussed in-depth below).
Variation in DNA loci responsible...
- 18.1 L/h for CYP2D6 ultra-rapid
metabolizers,
extensive metabolizers,
intermediate metabolizers, and poor
metabolizers. Area-under-the-curve
levels of...
- poor
metabolizers. In one
study on 252 Americans, 84.3% were
found to be "fast" (extensive)
metabolizers, 6.8% to be "intermediate"
metabolizers, and...
