- In
organic chemistry, the
Mannich reaction is a three-component
organic reaction that
involves the
amino alkylation of an
acidic proton next to a carbonyl...
- A
Mannich base is a beta-amino-ketone,
which is
formed in the
reaction of an amine,
formaldehyde (or an aldehyde) and a
carbon acid. The
Mannich base is...
- Carl
Ulrich Franz Mannich (8
March 1877 in
Breslau – 5
March 1947 in Karlsruhe) was a
German chemist. From 1927 to 1943 he was
professor for pharmaceutical...
- The
ketimine Mannich reaction is an
asymmetric synthetic technique using differences in
starting material to push a
Mannich reaction to
create an enantiomeric...
-
various classes of alkaloids,
including synthesis of
Schiff bases and
Mannich reaction.
Schiff bases can be
obtained by
reacting amines with ketones...
- The nitro-
Mannich reaction (or aza-Henry reaction) is the
nucleophilic addition of a
nitroalkane (or the
corresponding nitronate anion) to an imine, resulting...
- 2-aza-Cope
rearrangement with a
Mannich cyclization, and is the
subject of much of this article. This
tandem aza-Cope/
Mannich reaction is
characterized by...
-
exceeded 90%. This
reaction is
described as an
intramolecular "double
Mannich reaction" for
obvious reasons. It is not
unique in this regard, as others...
-
Similarly it is
prepared by the
Mannich reaction involving diethylammonium chloride and acetone,
which produces the
Mannich adduct: CH3C(O)CH3 + CH2O + [H2NEt2]Cl...
- reactions.
These modifications often include alkylations, acylations,
Mannich reactions, and
Michael additions. Such
alterations are
frequently explored...
