- rings. Instead,
medium sized rings or
polymers tend to form.
Early macrocyclizations were
achieved ketonic decarboxylations for the
preparation of terpenoid...
-
acyloin condensation can be deplo**** similarly. For
larger rings (
macrocyclizations) more
elaborate methods are
required since intramolecular ring closure...
- permeability. The
design of
class A
peptidomimetics often involves macrocyclization strategies as for
example in
stapled peptides. This
class of peptidomimetics...
- with
trifluoroacetic acid as a
catalyst to form a COF cage molecule.
Macrocyclizations have also been emplo**** to form
peptoid based macromolecular cages...
- 1074/jbc.M212364200. PMID 12569104. Kopp F,
Marahiel MA (August 2007). "
Macrocyclization strategies in
polyketide and
nonribosomal peptide biosynthesis". Natural...
-
products and
pharmaceuticals natural product discovery drug
discovery macrocyclizations using Cu(I)
catalyzed triazole couplings modification of DNA and nucleotides...
-
peptide (Figure 6).
Elongation by
these NRPS
modules ultimately leads to
macrocyclization and
release in
which an α-amino group,
namely threonine, acts as an...
-
directed syntheses are
mostly performed under kinetic control, when the
macrocyclization (catenation)
reaction is irreversible. More recently, the
groups of...
-
rings formed are
limited to 5 or 6 members,
however some
cases of
macrocyclization have been reported.
Unlike a
normal Stille coupling,
chlorine does...
-
cyclization is
especially slow for
small and
large rings (although
macrocyclizations,
which resemble intermolecular radical reactions, are
often high yielding)...