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Mexiletine (INN) (sold
under the
brand names Mexitil and Namuscla) is a
medication used to
treat abnormal heart rhythms,
chronic pain, and some causes...
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pacemakers and non-invasive
positive pressure ventilation. The
medications mexiletine or
carbamazepine can help
relax muscles. Pain, if it occurs, may be treated...
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mexiletine also
shortens the QT
interval in
other forms of long QT
syndrome including LQT1, LQT2 and LQT8. As the
predominant action of
mexiletine is...
- CYP1A2
inhibitors (such as zileuton,
certain antiarrhythmics (amiodarone,
mexiletine, propafenone, verapamil), cimetidine, famotidine, aciclovir, ticlopidine...
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mechanical allodynia –
compounds targeting different ion channels;
opioids Mexiletine Lidocaine (IV/topical)
Tramadol Morphine (IV)
Alfentanil (IV) Ketamine...
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class 1b
drugs lengthen phase 3 repolarization. They
include lidocaine,
mexiletine and phenytoin.
class Ic
greatly slow
phase 0
depolarization in the ventricles...
- with
antiarrhythmics if
hypokalemia occurs; the
effects of
lidocaine and
mexiletine are antagonized. Antibacterials:
increased risk of
ototoxicity with aminoglycosides...
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prevention of
ventricular fibrillation.
class Ib
agents include lidocaine,
mexiletine, tocainide, and phenytoin.
class Ic
antiarrhythmic agents markedly depress...
- quinine, ranolazine, procainamide, flecainide, phenytoin, carbamazepine,
mexiletine and
other anticonvulsant drugs.
Physical therapy and
other rehabilitative...
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include lidocaine, amiodarone, bretylium, flecainide, procainamide, and
mexiletine.
Cardiopulmonary byp**** is used if
symptoms are
refractory to treatment...
