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LipOXygenases DataBase Lipoxygenases iron-binding
region Archived 2019-09-12 at the
Wayback Machine in
PROSITE PDB: 1YGE –
structure of
lipoxygenase-1...
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valuable for
defining the
function of ALOX5 in
humans (see
Lipoxygenase § Mouse
lipoxygenases). ALOX5
exists primarily in the
cytoplasm and nucleoplasm...
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Arachidonate 5-
lipoxygenase inhibitors are
compounds that slow or stop the
action of the
arachidonate 5-
lipoxygenase (5-
lipoxygenase or 5-LOX) enzyme...
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substrate binding and
product stereochemistry issues in two
linoleate 9-
lipoxygenases". Lipids. 43 (11): 979–87. doi:10.1007/s11745-008-3230-1. PMC 4710486...
- ALOX15 (also
termed arachidonate 15-
lipoxygenase, 15-
lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like
other lipoxygenases, a
seminal enzyme in the metabolism...
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functions as a leukotriene-related
enzyme inhibitor (arachidonate 5-
lipoxygenase) or
leukotriene receptor antagonist (cysteinyl
leukotriene receptors)...
- with
rodent leukocyte-type Alox12 and Alox15 are
commonly termed 12/15-
lipoxygenases based on
their ability to
metabolize arachidonic acid to both 12(S)-HpETE...
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malignant stages; 15-HETE, 5-
lipoxygenase, 12-
lipoxygenase, and 15-
lipoxygenase-2, and
selected metabolites of the
latter lipoxygenases show no such ****ociation...
- acid (15(S)-HETE). The 15-
lipoxygenases (particularly ALOX15) may also act in
series with 5-
lipoxygenase, 12-
lipoxygenase, or aspirin-treated COX2 to...
- "Expression of
cloned human reticulocyte 15-
lipoxygenase and
immunological evidence that 15-
lipoxygenases of
different cell
types are related". The Journal...
