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Levorphanol (brand name Levo-Dromoran) is an
opioid medication used to
treat moderate to
severe pain. It is the
levorotatory enantiomer of the compound...
-
dextrorotatory enantiomer of racemorphan; the
levorotatory enantiomer is
levorphanol.
Dextrorphan is
produced by O-demethylation of
dextromethorphan by CYP2D6...
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about five
times stronger than morphine.
Levomethorphan is a
prodrug to
levorphanol,
analogously to DXM
acting as a
prodrug to
dextrorphan or
codeine behaving...
- by Bristol-Myers.
Butorphanol is most
closely structurally related to
levorphanol.
Butorphanol is
available as the
tartrate salt in injectable, tablet...
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opioids function additionally as NMDAR-antagonists, such as pethidine,
levorphanol, methadone, dextropropoxyphene, tramadol, and ketobemidone. Some NMDA...
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receptor antagonist)
Levorphanol – an
opioid analgesic It
analgesic activity is
intermediate between Dextrorphan and
Levorphanol.
Racemorphan itself is...
- Codeine;
Pholcodine Dextromethorphan;
Dimemorfan Racemorphan; Dextrorphan;
Levorphanol Pentoxyverine Tipepidine Cloperastine;
Levocloperastine Germouty J, Weibel...
- half-life and the
bioavailability of a drug. For example, the
narcotic levorphanol is 4–8
times stronger than morphine, but also has a much
longer half-life...
- μ-opioid receptor, and so
phenomorphan is
around 10x more
potent than
levorphanol,
which is
itself 6-8x the
potency of morphine.
Other analogues where...
-
clinically developed; a
prodrug of the
powerful opioid agonist analgesic levorphanol (Levo-Dromoran).
Racemethorphan is the
racemic mixture of both of these...
