-
Lanosterol is a
tetracyclic triterpenoid and is the
compound from
which all
animal and
fungal steroids are derived. By contrast,
plant steroids are produced...
-
cation and
finally to
lanosterol.
Lanosterol is a key four-ringed
intermediate in
cholesterol biosynthesis. In humans,
lanosterol synthase is
encoded by...
- are
manufactured in
cells from the
sterols lanosterol (opisthokonts) or
cycloartenol (plants).
Lanosterol and
cycloartenol are
derived from the cyclization...
-
Lanosterol 14α-demethylase (CYP51A1) is the
animal version of a
cytochrome P450
enzyme that is
involved in the
conversion of
lanosterol to 4,4-dimethylcholesta-8(9)...
-
intermediate in the
synthesis of the cell
membrane sterol precursors lanosterol and cycloartenol, as well as saponins. It is
formed when
squalene is oxidized...
- the
conversion of
squalene to
lanosterol. In fungi,
lanosterol is then
converted to ergosterol; in humans,
lanosterol becomes cholesterol. However, as...
-
Tocopherols Cholesterol Testosterone Cholecalciferol Ecdysones Other Betulin Lanosterol Saponins Serratenediol Squalane Acids Oleanolic acid
Ursolic acid Betulinic...
-
Rimocidin Azole antifungals inhibit the
conversion of
lanosterol to
ergosterol by
inhibiting lanosterol 14α-demethylase.
These compounds have a five-membered...
-
Synthase 1), and CYP51A1,
lanosterol 14-α-demethylase,
sometimes unofficially abbreviated to LDM
according to its
substrate (
Lanosterol) and
activity (DeMethylation)...
- binding,
while still allowing binding of the enzyme's
natural substrate,
lanosterol.
Development of
resistance to one
azole in this way will
confer resistance...
