-
coupling between an
amine and a
carboxylic acid
within the same molecule.
Lactamization is most
efficient in this way if the
product is a γ-lactam. For example...
-
orthogonal protection removed before undergoing a
carbodiimide mediated lactamization,
leading to an intermediate. This intermediate, when
attached to N-acetylnorleucine...
- this
represents the
formation of the
heterocyclic system by
simple lactamization.
Hydrazobenzene Diethyl n-butylmalonate Oxyphenbutazone, the
major metabolite...
- for solid-phase
peptide synthesis (SPPS), was
proven to
undergo rapid lactamization,
instead of
reacting with the N-terminal end of the peptide. Compared...
-
Ornithine lactamization...
- 4-α-ethoxycarbonylacetylamino-1,3-dimethyl-5-methylaminopyrazole (4). Base-catalyzed
lactamization gives (5). The
Goldberg reaction completes the
synthesis of zomebazam...
-
crown gall tumors.
Belongs to the
mannityl family. It is
formed by
lactamization of agropine.
Alanopine Beta-alanopine (2,2'-iminodipropionic acid or...
- 2-[(2-methoxy-2-oxoethyl)-methylcarbamoyl]benzoate, PC11644670 (4).
Intramolecular lactamization with
sodium methoxide afforded Methyl 4-hydroxy-2-methyl-1-oxoisoqu...
- benzopiperazinones, and benzodiazepinones, are
efficiently prepared.
Lactamization reactions are
commonly emplo**** to form the heterocycles,
usually under...
-
product might be
expected to be
initially formed (5'). An
intramolecular lactamization to the
heterocyclic ring then
occurs giving altanserin (6). Ketanserin...
