-
Lactacystin is an
organic compound naturally synthesized by
bacteria of the
genus Streptomyces first identified as an
inducer of
neuritogenesis in neuroblastoma...
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Lactacystin was
licensed to Myogenics/Proscript,
which was
acquired by
Millennium Pharmaceuticals, now part of
Takeda Pharmaceuticals.
Lactacystin covalently...
- near lake from Inba in ****an.
Streptomyces lactacystinicus produces lactacystin and cyslabdan. List of
Streptomyces species Parte, A.C. "Genus Streptomyces"...
- from the
Ishigaki Island in ****an.
Streptomyces cyslabdanicus produces lactacystin and cyslabdan. List of
Streptomyces species Parte, A.C. "Genus Streptomyces"...
- prostaglandins.
Other notable syntheses:
Longifolene Ginkgolides A and B
Lactacystin Miroestrol Ecteinascidin 743
Salinosporamide A
Corey and his research...
- non-peptidic
proteasome inhibitor discovered was the
natural product lactacystin.
Disulfiram has been
proposed as
another proteasome inhibitor....
- of
protein kinase named staurosporine; a
proteasome inhibitor named lactacystin; a
fatty acid
biosynthesis inhibitor named cerulenin; Furthermore, compounds...
- PMID 10468620. Schwarz, K.; et al. (2000). "The
selective proteasome inhibitors lactacystin and
epoxomicin can be used to
either up- or down-regulate
antigen presentation...
-
natural products such as trichoviridin,
acromelic acid A,
hypoglycin A and
lactacystin; and
biomimetic synthesis of
natural products such as (-)-xestospongin...
- tumors. In 1995,
Schreiber and co-workers
found that the
small molecule lactacystin binds and
inhibits specific catalytic subunits of the proteasome, a protein...
