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Kynurenic acid (KYNA or KYN) is a
product of the
normal metabolism of
amino acid L-tryptophan. It has been
shown that
kynurenic acid
possesses neuroactive...
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Metabolites involved in the
kynurenine pathway include tryptophan, kynurenine,
kynurenic acid,
xanthurenic acid,
quinolinic acid, and 3-hydroxykynurenine. The...
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levels of
another NMDA antagonist,
kynurenic acid, may
aggravate the
symptoms of schizophrenia,
according to the "
kynurenic hypothesis". NMDA
receptor antagonists...
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neuroactive intermediates including quinolinic acid,
kynurenine (KYN),
kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), and 3-hydroxyanthranilic acid...
- 5-Fluorowillardiine,
Domoic acid,
Quisqualic acid, etc. Antagonists: CNQX,
Kynurenic acid, NBQX, Perampanel, Piracetam, etc.
Positive allosteric modulators:...
- riluzole, memantine,
methoxetamine (MXE),
methoxphenidine (MXP) and
kynurenic acid.
While dizocilpine is
generally considered to be the prototypical...
- 3-hydroxy-L-kynurenine via
kynurenine 3-monooxygenase, the
neuroprotectant kynurenic acid
through kynurenine amino transferases, or
anthranilic acid by kynureninase...
- the
glycine site of the NMDA
receptor complex. 7-Chlorokynurenic acid
Kynurenic acid
McNamara D,
Smith EC,
Calligaro DO, O'Malley PJ,
McQuaid LA, Dingledine...
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Caroverine CNQX
Dasolampanel DNQX
Fanapanel (MPQX) GAMS
Kaitocephalin Kynurenic acid
Kynurenine Licostinel (ACEA-1021) NBQX PNQX
Selurampanel Tezampanel...
-
while kynurenine-oxoglutarate
transaminase catalyzes its
conversion into
kynurenic acid.
Kynurenine 3-hydroxylase
catalyzes the
conversion of kynurenine...
