-
Antagonist Human MOR2Tooltip μ-Opioid
receptor 12.1 Ki
Antagonist Human KORTooltip κ-Opioid
receptor 28 25 Ki Ki
Antagonist Agonist Human σ2 26 Ki ND Rat...
- constant)
Ratio Ref
MORTooltip μ-Opioid
receptor DORTooltip δ-Opioid
receptor KORTooltip κ-Opioid
receptor MOR:DOR:KOR
Morphine 1.8 nM 90 nM 317 nM 1:50:176 (−)-Morphine...
-
Ratios Refs
MORTooltip μ-Opioid
receptor DORTooltip δ-Opioid
receptor KORTooltip κ-Opioid
receptor MOR:DOR:KOR
Naloxone 1.1 nM 1.4 nM 16 nM 67.5 nM 12...
-
Ratio Ref.
MORTooltip μ-Opioid
receptor DORTooltip δ-Opioid
receptor KORTooltip κ-Opioid
receptor MOR:DOR:KOR
Oxycodone 18 nM 958 nM 677 nM 1:53:38 Oxymorphone...
-
receptor >10,000 ND
Human DORTooltip δ-Opioid
receptor >10,000 ND
Human KORTooltip κ-Opioid
receptor >10,000 ND
Human NOPTooltip Nociceptin receptor >10...
- constant)
Ratio Ref
MORTooltip μ-Opioid
receptor DORTooltip δ-Opioid
receptor KORTooltip κ-Opioid
receptor MOR:DOR:KOR
Hydrocodone 11.1 nM 962 nM 501 nM 1:87:45...
- 1280 ND 420 1000+ Rat
Human DORTooltip δ-Opioid
receptor 11500 34700 Rat
KORTooltip κ-Opioid
receptor 7000 5950 Rat
SERTTooltip Serotonin transporter 23–40...
-
DORTooltip δ-Opioid
receptor >10,000 57,600–100,000 ≥2,900 690 (+))
Human Rat
KORTooltip κ-Opioid
receptor >10,000 42,700–81,000 ≥450 1,800 (+))
Human Rat SERTTooltip...
- 38%±10
DORTooltip δ-Opioid
receptor 2.9–6.1 0.82
Antagonist Human Monkey 0
KORTooltip κ-Opioid
receptor 0.62–2.5 0.44 Antagonist/weak
partial agonist (dose...
-
constant Ratio MORTooltip μ-opioid
receptor DORTooltip δ-opioid
receptor KORTooltip κ-opioid
receptor MOR:DOR:KOR 0.39 nM >1,000 nM 255 nM 1:>2564:654...
