-
JDTic is a selective, long-acting ("inactivating")
antagonist of the κ-opioid
receptor (KOR).
JDTic is a 4-phenylpiperidine derivative,
distantly related...
- (KOR). It was
derived from the
irreversible (long-acting) KOR
antagonist JDTic in
search of an
antagonist with a
reversible profile of
inactivation of...
- the
treatment of
major depressive disorder and
substance use disorders.
JDTic and PF-4455242 were also
under investigation but
development was halted...
- this
could be
challenged in court.
Binaltorphimine 5'-Guanidinonaltrindole
JDTic Munro TA,
Huang XP,
Inglese C,
Perrone MG, Van't Veer A,
Carroll FI, et al...
- non-inactivating
antagonist of the KOR (as
opposed to
irreversible antagonists like
JDTic).
Although originally characterized as a KOR
neutral antagonist however...
-
Hyperoside JDTic LY-255582 LY-2196044 LY-2444296 LY-2459989 LY-2795050 Me
JDTic Methylnaltrexone ML190 ML350 MR-2266 N-Fluoropropyl-
JDTic Naloxone Naltrexone...
-
Hyperoside JDTic LY-255582 LY-2196044 LY-2444296 LY-2459989 LY-2795050 Me
JDTic Methylnaltrexone ML190 ML350 MR-2266 N-Fluoropropyl-
JDTic Naloxone Naltrexone...
- dependence, as are
other KOR
antagonists such as
aticaprant and, previously,
JDTic and PF-4455242 (both
discontinued due to
toxicity concerns). All of the...
- (March 2012). "Structure of the
human κ-opioid
receptor in
complex with
JDTic". Nature. 485 (7398): 327–32. Bibcode:2012Natur.485..327W. doi:10.1038/nature10939...
- Diacetylnalorphine [52] Diprenorphine (M5050)
Fedotozine ICI-174864 J-113,397
JDTic JTC-801
Levallorphan LY-2456302 LY-255582
Methocinnamox Methylnaltrexone...
