-
classical Isosteres are
molecules or ions with
similar shape and
often electronic properties. Many
definitions are available. but the term is
usually emplo****...
-
carbon center has been
replaced by
isosteric silicon, and in addition, one
hydrogen atom is
replaced by
isosteric fluorine atom.
Bioisosteres of some...
- side
chain substitution,
structural bond
extension cyclization, and
isosteric replacements within the
amino acid backbone. Many non-proteinogenic amino...
- only slowly.
Protonation of the
conjugate base O2NCH2−,
which is
nearly isosteric with nitrate,
occurs initially at oxygen. In
organic synthesis nitromethane...
- side
chain substitution,
structural bond
extension cyclization, and
isosteric replacements within the
amino acid backbone.
Based on
their similarity...
- of
oxamic acid.
Oxamate has a
molecular formula of C2H2NO3− and is an
isosteric form of pyruvate.
Salts and
esters of
oxamic acid are
known collectively...
- mutations) in DNA
replication and DNA transcription. This is due to
their isosteric chemistry. One
common mutagenic base
analog is 5-bromouracil,
which resembles...
-
amino acids,
norleucine and
especially norvaline are formed. It is
nearly isosteric with methionine, even
though it does not
contain sulfur. For this reason...
-
disrupting the
overall structure.
These base
pairs are
called isosteric base pairs.
Isosteric base
pairs always belong to same
geometric families, but all...
-
Catalonia for
designing photochromic analogs of
tricyclic drugs via (1)
isosteric replacement of the two-atom
bridge between the
aromatic systems with an...
