Definition of Isosteres. Meaning of Isosteres. Synonyms of Isosteres

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Definition of Isosteres

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Meaning of Isosteres from wikipedia

- Non-classical isosteres do not obey the above classifications, but they still produce similar biological effects in vivo. Non-classical isosteres may be made...
- Non-canonical base pairs are planar hydrogen bonded pairs of nucleobases, having hydrogen bonding patterns which differ from the patterns observed in Watson-Crick...
- transport. Furthermore, their geometry and stability make them suitable isosteres for benzene rings. The classic 1964 synthesis starts with the conversion...
- require hematological monitoring. Investigation on a series of thiophene isosteres on 1 of the phenyl rings in clozapine, a thienobenzodiazepine analog (olanzapine)...
- Mills, J. S. (2003). "Chemistry Challenges in Lead Optimization: Silicon Isosteres in Drug Discovery". Drug Discovery Today. 8 (12): 551–556. doi:10...
- is a derivative of anthranilic acid,: 235  which in turn is a nitrogen isostere of salicylic acid, which is the active metabolite of aspirin.: 235 : 17 ...
- compound can be classified as a cyclic amide, and as such is used as an isostere for peptides and other pharmaceutically inspired targets. The 4-methyl-2-quinolone...
- the bases pair thanks to hydrophobicity, as studies have shown with DNA isosteres (analogues with same number of atoms) such as the thymine analogue 2,4-difluorotoluene...
- 3-indenealkylamines and 3-benzo[b]thiophenealkylamines with their tryptamine isosteres". Journal of Medicinal Chemistry. 10 (5): 856–858. doi:10.1021/jm00317a022...
- Grimm, each vertical column (of Table below) would represent a group of isosteres. ^ Grimm, H. G. Structure and Size of the Non-metallic Hydrides Z. Electrochem...