- Non-classical
isosteres do not obey the
above classifications, but they
still produce similar biological effects in vivo. Non-classical
isosteres may be made...
- Non-canonical base
pairs are
planar hydrogen bonded pairs of nucleobases,
having hydrogen bonding patterns which differ from the
patterns observed in Watson-Crick...
- transport. Furthermore,
their geometry and
stability make them
suitable isosteres for
benzene rings. The
classic 1964
synthesis starts with the conversion...
- Mills, J. S. (2003). "Chemistry
Challenges in Lead Optimization:
Silicon Isosteres in Drug Discovery". Drug
Discovery Today. 8 (12): 551–556. doi:10...
-
require hematological monitoring.
Investigation on a
series of
thiophene isosteres on 1 of the
phenyl rings in clozapine, a
thienobenzodiazepine analog (olanzapine)...
- is a
derivative of
anthranilic acid,: 235
which in turn is a
nitrogen isostere of
salicylic acid,
which is the
active metabolite of aspirin.: 235 : 17 ...
- the
bases pair
thanks to hydrophobicity, as
studies have
shown with DNA
isosteres (analogues with same
number of atoms) such as the
thymine analogue 2,4-difluorotoluene...
-
compound can be
classified as a
cyclic amide, and as such is used as an
isostere for
peptides and
other pharmaceutically inspired targets. The 4-methyl-2-quinolone...
- Grimm, each
vertical column (of
Table below)
would represent a
group of
isosteres. ^ Grimm, H. G.
Structure and Size of the Non-metallic
Hydrides Z. Electrochem...
- 3-indenealkylamines and 3-benzo[b]thiophenealkylamines with
their tryptamine isosteres".
Journal of
Medicinal Chemistry. 10 (5): 856–858. doi:10.1021/jm00317a022...
