-
strand (intrastrand) or
between opposite strands of double-stranded DNA (
interstrand).
These adducts interfere with
cellular metabolism, such as DNA replication...
- atom
forms the
second alkylation step that
results in the
formation of
interstrand cross-links (ICLs) as it was
shown in the
early 1960s. At that time,...
- PMID 11226027.
Marchetti F,
Bishop J,
Gingerich J,
Wyrobek AJ (2015). "Meiotic
interstrand DNA
damage escapes paternal repair and
causes chromosomal aberrations...
- or XPF are
especially sensitive to
agents that
cause DNA
interstrand crosslinks.
Interstrand crosslinks block the
progression of DNA replication, and...
- Noll DM,
Mason TM,
Miller PS (February 2006). "Formation and
repair of
interstrand cross-links in DNA".
Chemical Reviews. 106 (2): 277–301. doi:10.1021/cr040478b...
- PMID 17978187.
Marchetti F,
Bishop J,
Gingerich J,
Wyrobek AJ (2015). "Meiotic
interstrand DNA
damage escapes paternal repair and
causes chromosomal aberrations...
-
treatment of
vitiligo and hand eczema.
After photoactivation it
creates interstrand cross-links in DNA,
which can
cause programmed cell
death unless repaired...
-
alkylating agent,
alkylates both DNA and RNA, has the
ability to
created interstrand cross-links (ICLs) in DNA. As with
other nitrosoureas, it may also inhibit...
-
Repair of DNA in
which the two
complementary strands are
joined by an
interstrand covalent crosslink requires multiple incisions in
order to disengage...
-
damaged sites, and its
recruitment is most
rapid and
robust as follows:
interstrand crosslinks > double-strand
breaks >
monoadducts >
oxidative damage. CSB...
