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Indolin-2-one
monooxygenase (EC 1.14.13.138, BX3 (gene), CYP71C2 (gene)) is an
enzyme with
systematic name
indolin-2-one,NAD(P)H:oxygen oxidoreductase...
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potency and
selectivity and
gives an IC50 of 3nM
against the receptor.
Indolin derivatives on the
market are
Sunitinib and Intedanib. Two
indol derivatives...
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tyrindoxyl sulphate. The
molecule consists of a pair of
monobrominated indolin-3-one
rings linked by a carbon-carbon
double bond.
Dibromoindigo can also...
- 14.14.153, indole-2-monooxygenase EC 1.14.13.138: Now EC 1.14.14.157,
indolin-2-one
monooxygenase EC 1.14.13.139: Now EC 1.14.14.109, 3-hydroxyindolin-2-one...
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Dallanoce C (April 17, 2014). "A
convenient synthesis of 4-(2-hydroxyethyl)
indolin-2-one, a
useful intermediate for the
preparation of both
dopamine receptor...
- (February 2007). "SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)
indolin-2-one], a
novel mixed nociceptin/orphanin FQ/mu-opioid
receptor partial...
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Identifiers IUPAC name 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)
indolin-1-yl]-2-(3-trifluoromethylphenyl)ethanone CAS
Number 1337531-36-8 Y PubChem...
- W.T. (2018). "Synthesis of Indoline-2,3-diones by
Radical Coupling of
Indolin-2-ones with tert-Butyl Hydroperoxide". Synlett. 29 (2): 215–218. doi:10...
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reaction indole + NAD(P)H + H+ + O2 ⇌ {\displaystyle \rightleftharpoons }
indolin-2-one + NAD(P)+ + H2O Indole-2-monooxygenase is
involved in the biosynthesis...
- Later,
series of more
selective c-Met
inhibitors were designed,
where an
indolin-2-one core (encircled in
figure 1) was
present in
several kinase inhibitors...
