-
Immunoconjugates are
antibodies conjugated (joined) to a
second molecule,
usually a toxin,
radioisotope or label.
These conjugates are used in immunotherapy[citation...
- cBR96-doxorubicin
immunoconjugate (BMS-182248/SGN-15; also
known as cBR96-Dox) is an antibody-drug
conjugate or (ADC)
directed to the Lewis-Y antigen...
- drug. Antibody–drug
conjugates are an
example of
bioconjugates and
immunoconjugates. ADCs
combine the
targeting properties of
monoclonal antibodies with...
-
extremely toxic to all
cells and, in 2000, a CD33 antigen-targeted
immunoconjugate N-acetyl
dimethyl hydrazide calicheamicin was
developed and marketed...
-
protein crosslinking to
nucleic acids, but also in the
preparation of
immunoconjugates. EDC is
often used in
combination with N-hydroxysuccinimide (NHS) for...
- This
study can be
performed in
vitro (reactivity of the
antibody or
immunoconjugate should be
determined with a quick-frozen
adult tissues) or in vivo...
-
coupling a
murine monoclonal antibody with
doxorubicin created an
immunoconjugate that was able to
eliminate HIV-1
infection in mice.
There is some evidence...
-
ovarian cancer,
malignant ascites,
gastric cancer cBR96-doxorubicin
immunoconjugate mab
humanized Lewis-Y
antigen cancer Cedelizumab mab
humanized CD4...
- PMID 1330289. Safa, Malek; Foon,
Kenneth A.; Oldham,
Robert K. (2009). "Drug
Immunoconjugates". In Oldham,
Robert K.; Dillman,
Robert O. (eds.).
Principles of Cancer...
- Dibirdik, Ilker; Myers,
Dorothea E. (2012-09-18). "Rational
design of an
immunoconjugate for
selective knock-down of leukemia-specific E2A–PBX1
fusion gene...
