- An
iminosugar, also
known as an iminosaccharide, is any
analog of a
sugar where a
nitrogen atom has
replaced the
oxygen atom in the ring of the structure...
-
collectively as
pyrrolizidine alkaloids. It is one of five
classes of
iminosugars.
These are
often synthesized from a carbohydrate.
Pyrrolizidine alkaloids...
-
Castanospermine is an
indolizidine alkaloid first isolated from the
seeds of
Castanospermum australe. It is a
potent inhibitor of some
glucosidase enzymes...
- 1-Deoxynojirimycin (DNJ or 1-DNJ), also
called duvoglustat or moranolin, is an alpha-glucosidase inhibitor, most
commonly found in
mulberry leaves. Although...
-
strains of streptomycetes, e.g.
Streptomyces azureus. Nojirimycin, an
iminosugar from a
class of
Streptomyces species. Tetrodotoxin, a
neurotoxin produced...
- N-acetylation will
furnish the
desired 2-N-acetamido-2-deoxyglycosides.
Iminosugar N-Acetylglucosamine
Galactosamine Glucosamine Sialic acid L-Daunosamine...
-
Swainsonine is an
indolizidine alkaloid. It is a
potent inhibitor of
Golgi alpha-mannosidase II, an immunomodulator, and a
potential chemotherapy drug...
- has a
nitrogen atom in the ring
instead of an oxygen,
which makes it an
iminosugar. The
structure is
formally derived from nojirimycin.[citation needed]...
- doesn't work; this is
called substrate reduction therapy.
Miglustat is an
iminosugar, a
synthetic analogue of D-glucose and a
white to off-white crystalline...
- Celgosivir, in
development by
Migenix for the
treatment of
hepatitis C
virus (HCV) infection, is an oral
prodrug of the
natural product castanospermine...
