Definition of Hypermutation. Meaning of Hypermutation. Synonyms of Hypermutation

- Somatic hypermutation (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes)...
- experimental results in the fields of epigenetics, genetics, and somatic hypermutation proved the possibility of transgenerational epigenetic inheritance of...
- (AID) that is essential for class switch recombination and somatic hypermutation. He was elected as a foreign ****ociate of the National Academy of Sciences...
- undergo a high rate of point mutation, by a process called somatic hypermutation (SHM). SHM results in approximately one nucleotide change per variable...
- proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at achieving higher affinity) during a normal immune response;...
- outside the lymphoid system. A major step in affinity maturation, somatic hypermutation helps B cells produce antibodies with greater antigen affinity. Somatic...
- Reed–Sternberg cells have undergone both V(D)J recombination and somatic hypermutation, establishing an origin from a germinal center or postgerminal center...
- class switch from IgM/IgD to other antibody isotypes and drives somatic hypermutation during clonal proliferation. The switched antibodies acquire better...
- promotes B cell proliferation, immunoglobulin class switching, and somatic hypermutation as well as sustains T cell growth and differentiation. T cell-derived...
- of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes...