-
Somatic hypermutation (or SHM) is a
cellular mechanism by
which the
immune system adapts to the new
foreign elements that
confront it (e.g. microbes)...
-
experimental results in the
fields of epigenetics, genetics, and
somatic hypermutation demonstrated the
possibility of
transgenerational epigenetic inheritance...
- of the
cytidine deaminase family. The
protein is
involved in
somatic hypermutation, gene conversion, and class-switch
recombination of
immunoglobulin genes...
-
undergo a high rate of
point mutation, by a
process called somatic hypermutation (SHM). SHM
results in
approximately one
nucleotide change per variable...
- (AID) that is
essential for
class switch recombination and
somatic hypermutation. He was
elected as a
foreign ****ociate of the
National Academy of Sciences...
-
specialised structures called germinal centers. This
process involves somatic hypermutation,
resulting in
genetic changes that
enhance the antibody's affinity....
- Reed–Sternberg
cells have
undergone both V(D)J
recombination and
somatic hypermutation,
establishing an
origin from a
germinal center or
postgerminal center...
-
promotes B cell proliferation,
immunoglobulin class switching, and
somatic hypermutation as well as
sustains T cell
growth and differentiation. T cell-derived...
-
immunoglobulin of
germinal center B
cells and as a
direct result of
somatic hypermutation (SHM) and
selection by TFH cells. The
process is
thought to involve...
- proliferate, differentiate, and
mutate their antibody genes (through
somatic hypermutation aimed at
achieving higher affinity)
during a
normal immune response;...
