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Microsatellite instability (MSI) is the
condition of
genetic hypermutability (predisposition to mutation) that
results from
impaired DNA
mismatch repair...
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contain minisatellite-like sequences, none was
found to be
hypermutable.
Since all
hypermutable minisatellites contain internal variants, they
provide extremely...
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stimulates Lac(+)
reversion (adaptive mutation) with or
without general hypermutability". Genetics. 161 (3): 945–956. doi:10.1093/genetics/161.3.945. PMC 1462195...
- the same species; for example,
bacteria have been
observed to
evolve hypermutability as they
adapt to new
selective conditions.
These different rates of...
-
identified a
number of
genes that, when
mutationally inactivated,
cause hypermutable strains. The gene
products are, therefore,
called the "Mut" proteins...
- of the
presence of
mutated PMS2.
Overexpression of PMS2
results in
hypermutability and DNA
damage tolerance.
Deficiency of PMS2 also
contributes to genetic...
- L., Luhar, R., Yung, M., & Miller, J. H. (2016).
Mutagen Synergy:
Hypermutability Generated by
Specific Pairs of Base Analogs.
Journal of bacteriology...
-
challenged in 2002, by work
showing that the
phenomenon was due to
general hypermutability due to
selected gene amplification,
followed by
natural selection,...
- DA (2012). "Base
damage within single-strand DNA
underlies in vivo
hypermutability induced by a
ubiquitous environmental agent". PLOS Genetics. 8 (12):...
- skin cancer, and at the
cellular level, by dela****
replication and
hypermutability after UV-irradiation POLH has been
shown to
interact with PCNA. GRCh38:...
