- neuron. Such
heteromers may be
between receptors from the same
family (e.g.,
adenosine A1/A2A
heteromers and
dopamine D1/D2 and D1/D3
heteromers) or between...
-
receptors appear to
exist as
heteromers. The 'high-affinity'
subunits GluK4 and GluK5 can only form
functional channels as
heteromers with 'low-affinity' subunits...
- the
striatum by
binding to
adenosine receptors that have
formed GPCR
heteromers with
dopamine receptors,
specifically the A1–D1
receptor heterodimer (this...
- A2A
receptor are
complicated by the fact that a
variety of
functional heteromers composed of a
mixture of A2A
subunits with
subunits from
other unrelated...
- LA (September 2014). "Revolution in GPCR signalling:
opioid receptor heteromers as
novel therapeutic targets:
IUPHAR review 10".
British Journal of Pharmacology...
-
Benneyworth MA,
Thomas MJ, et al. (August 2014). "****tive
kappa opioid heteromers as
targets for
developing analgesics free of
adverse effects". Journal...
- regulation.
Chronic THC
increased the
number of D1-D2
heteromer-expressing neurons, and the
number of
heteromers within individual neurons in
adult monkey striatum...
-
Especially the D2
receptor is
considered a
major hub
within the GPCR
heteromer network.
Protomers consist of
Isoreceptors D1–D2 D1–D3 D2–D3 D2–D4 D2–D5...
-
presumed to be
pentameric heteromers of the alpha-1 and beta subunits, in
either a 3:2 or 2:3 ratio.
Within these heteromers, it is
believed that the alpha-1...
-
systems in the
central nervous system is reduced. The
GABAA receptor is a
heteromer composed of five subunits, the most
common ones
being two αs, two βs,...
