- In biochemistry, a
protein dimer is a
macromolecular complex or
multimer formed by two
protein monomers, or
single proteins,
which are
usually non-covalently...
-
constitutive activation, or
mutation alone is oncogenic, the
protein as a
heterodimerization partner, most
critically with ErbB2, is
implicated in growth, proliferation...
- HER2 does not
directly bind ligand. HER2
activation results from
heterodimerization with
another ERBB
member or by
homodimerization when HER2 concentration...
- in what is
predicted to be a
hexose transporter. The
product then
heterodimerizes with the susceptible's product, with the
downstream result of reducing...
-
GABAB receptor. This so-called
constitutive receptor is
formed by
heterodimerization of GABABR1 and GABABR2 subunits.
Expression of the GABABR1 without...
- (1998). "The
first constant domain (CH1 and CL) of an
antibody used as
heterodimerization domain for
bispecific miniantibodies". FEBS Letters. 422 (2): 259–264...
-
emicizumab (formerly RG6013) is an IgG
derivative containing H-chain
heterodimerization motifs,
which was
combined with the
common light chain approach to...
- ERK,
which causes translocation to the nucleus. In the
nucleus β2
heterodimerizes with E47,
binds to the E1
element of the
insulin promoter and recruits...
- "Amitriptyline is a TrkA and TrkB
receptor agonist that
promotes TrkA/TrkB
heterodimerization and has
potent neurotrophic activity".
Chemistry & Biology. 16 (6):...
- analgesia,
whereas the
alternatively spliced MOR1D
isoform (through
heterodimerization with the gastrin-releasing
peptide receptor) is
required for morphine-induced...
