Definition of Heparanases. Meaning of Heparanases. Synonyms of Heparanases

- DS, Li JP, Vlodavsky I, Lindahl U (1998). "Substrate specificity of heparanases from human hepatoma and platelets". J. Biol. Chem. 273 (30): 18770–7...
- unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Heparanase Bame KJ (June 2001). "Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans"...
- clots to form. Moreover, most malignant tumors overexpress and secrete heparanase, an enzyme that degrade heparan sulfate and endogenous heparin, and thus...
- antiadhesive, antimetastatic Phosphomannopentanose sulfate Potent inhibitor of heparanase activity Antimetastatic, antiangiogenic, anti-inflammatory Selectively...
- due to treatment with antineoplastic medications; and (3) secretion of heparanase from malignant tumors that results in degradation of endogenous heparin...
- and nuclear translocation of mitogen-activated protein (MAP) kinases. Heparanase cleaves heparin sulfate chains of HSPGs, which have an extensive network...
- 2009). "Screening and identification of novel B cell epitopes in human heparanase and their anti-invasion property for hepatocellular carcinoma". Cancer...
- Diagram showing a pancreatic islet and four stages of T1D disease driven by heparanase and loss of intra-islet glycosaminoglycan heparan sulfate (HS)...
- syndecan-1 only after heparanase modification. Binding utilizes an enzyme-regulated 'off-on' switch in which active epithelial heparanase (HPSE) cleaves off...
- identical cells. Heparan sulfate analogues cannot be degraded by all known heparanases and glycanases and bind to the free heparin sulfate binding spots on...