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Heparanase, also
known as HPSE, is an
enzyme that acts both at the cell-surface and
within the
extracellular matrix to
degrade polymeric heparan sulfate...
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clots to form. Moreover, most
malignant tumors overexpress and
secrete heparanase, an
enzyme that
degrade heparan sulfate and
endogenous heparin, and thus...
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Heparanase (EC 3.2.1.166, Hpa1
heparanase, Hpa1,
heparanase 1,
heparanase-1, C1A
heparanase, HPSE) is an
enzyme with
systematic name
heparan sulfate...
- and
nuclear translocation of mitogen-activated
protein (MAP) kinases.
Heparanase cleaves heparin sulfate chains of HSPGs,
which have an
extensive network...
- syndecan-1 only
after heparanase modification.
Binding utilizes an enzyme-regulated 'off-on'
switch in
which active epithelial heparanase (HPSE)
cleaves off...
- antiadhesive,
antimetastatic Phosphomannopentanose sulfate Potent inhibitor of
heparanase activity Antimetastatic, antiangiogenic, anti-inflammatory Selectively...
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Diagram showing a
pancreatic islet and four
stages of T1D
disease driven by
heparanase and loss of intra-islet
glycosaminoglycan heparan sulfate (HS)...
- due to
treatment with
antineoplastic medications; and (3)
secretion of
heparanase from
malignant tumors that
results in
degradation of
endogenous heparin...
-
Heparanase-2 is an
enzyme that in
humans is
encoded by the HPSE2 gene. It may be ****ociated with
urofacial syndrome. GRCh38:
Ensembl release 89: ENSG00000172987...
-
hydrolase family 79
includes endo-beta-N-glucuronidase EC 3.2.1.31 and
heparanase (CAZY GH_79).
Heparan sulphate proteoglycans (HSPGs) play a key role in...
