Definition of Heparanase. Meaning of Heparanase. Synonyms of Heparanase

- Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate...
- clots to form. Moreover, most malignant tumors overexpress and secrete heparanase, an enzyme that degrade heparan sulfate and endogenous heparin, and thus...
- Heparanase (EC 3.2.1.166, Hpa1 heparanase, Hpa1, heparanase 1, heparanase-1, C1A heparanase, HPSE) is an enzyme with systematic name heparan sulfate...
- and nuclear translocation of mitogen-activated protein (MAP) kinases. Heparanase cleaves heparin sulfate chains of HSPGs, which have an extensive network...
- syndecan-1 only after heparanase modification. Binding utilizes an enzyme-regulated 'off-on' switch in which active epithelial heparanase (HPSE) cleaves off...
- antiadhesive, antimetastatic Phosphomannopentanose sulfate Potent inhibitor of heparanase activity Antimetastatic, antiangiogenic, anti-inflammatory Selectively...
- Diagram showing a pancreatic islet and four stages of T1D disease driven by heparanase and loss of intra-islet glycosaminoglycan heparan sulfate (HS)...
- due to treatment with antineoplastic medications; and (3) secretion of heparanase from malignant tumors that results in degradation of endogenous heparin...
- Heparanase-2 is an enzyme that in humans is encoded by the HPSE2 gene. It may be ****ociated with urofacial syndrome. GRCh38: Ensembl release 89: ENSG00000172987...
- of tissue injury, the soluble syndecan-1 ectodomains are cleaved by heparanases, producing heparin-like fragments that activate bFGF [13]. Whereas most...