-
Hemojuvelin (HJV), also
known as
repulsive guidance molecule C (RGMc) or
hemochromatosis type 2
protein (HFE2), is a membrane-bound and
soluble protein...
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involves mutations in
genes coding for the iron
regulatory proteins hemojuvelin,
transferrin receptor-2 and ferroportin.
Hereditary hemochromatosis is...
-
suggests a
potential mechanism to
generate the
soluble forms of HJV/
hemojuvelin (s-
hemojuvelin)
found in the
blood of
rodents and humans. The
furin substrates...
-
suggests a
potential mechanism to
generate the
soluble forms of HJV/
hemojuvelin (s-
hemojuvelin)
found in the
blood of
rodents and humans. The two proprotein...
- parent, for the HJV (aka HFE2) gene,
which encodes the
protein hemojuvelin.
Hemojuvelin is
responsible for the
maintaining correct levels of the protein...
-
majority of
juvenile hemochromatosis cases are
caused by
mutations in
hemojuvelin.
Mutations in TMPRSS6 can
cause anemia through dysregulation of hepcidin...
-
hepcidin deficiency. The
majority of
cases are
caused by
mutations in the
hemojuvelin gene (HJV or RGMc/repulsive
guidance molecule c). The exceptions, people...
- were homozygotic. The G320V
mutation in the HJV gene,
which produces hemojuvelin protein, is
widely distributed in
central Europe and Greece. The term...
- is a
hereditary hemochromatosis caused by
mutations of a gene
called hemojuvelin.
While the
symptoms and
outcomes for
these two
diseases are similar,...
-
family (in vertebrates)
composed of RGMa, RGMb, and RGMc (also
called hemojuvelin). RGMa has been
implicated to play an
important role in the developing...
