- In
organic chemistry,
hemithioacetals (or thiohemiacetals) are
organosulfur compounds with the
general formula R−CH(−OH)−SR’. They are the
sulfur analogues...
-
attacks the
carbonyl group of G3P,
creating a
hemithioacetal intermediate (covalent catalysis). The
hemithioacetal is
deprotonated by a
histidine residue in...
-
detoxified by glutathione.
Glutathione reacts with
methylglyoxal to give a
hemithioacetal,
which converted into S-D-lactoyl-glutathione by
glyoxalase I. This...
-
reactions proceed via the
intermediacy of
hemithioacetals (R−CH(−OH)−SR'):
Thiol addition to give
hemithioacetal: RSH + R ′ CH ( O ) ⟶ R ′ CH ( SR ) OH {\displaystyle...
- 4.4.1.5, also
known as
glyoxalase I)
catalyzes the
isomerization of
hemithioacetal adducts,
which are
formed in a
spontaneous reaction between a glutathionyl...
-
clinically effective. Instead,
alternative chemicals such as sulfanegen, the
hemithioacetal cyclic dimer of 3-MP, are
being evaluated that
produce 3-MP in vivo...
-
glyoxalase І,
which catalyzes the
isomerization of the
spontaneously formed hemithioacetal adduct between glutathione and 2-oxoaldehydes (such as methylglyoxal)...
- lyase.
Prenylcysteine oxidase 1,
symbol PCYOX1, gene on
chromosome 2
Hemithioacetals in nature, for
mechanism of
action Flavin adenine dinucleotide, cofactor...
-
conversion of free
methylglyoxal present in fast
equilibrium with
hemithioacetals and hemiaminals".
Journal of
Biological Chemistry. 294 (49): 18863–18872...
-
identification of β-galactosidase
inhibitors from a
virtual dynamic hemithioacetal system". Angew. Chem. Int. Ed. 49 (3): 589–593. doi:10.1002/anie.200903920...
