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Halichondrin B is a
polyether macrolide originally isolated from the
marine sponge Halichondria okadai by
Hirata and
Uemura in 1986. In the same report...
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fully synthetic macrocyclic ketone analog of the
marine natural product halichondrin B, the
parent molecule being a
naturally occurring,
potent mitotic inhibitor...
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Halichondria produces the
eribulin precursor halichondrin B...
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through the
discovery of cell
division limiting properties of the
extract Halichondrin B,
which inhibits cell mitosis. The drug Eribulin, a
related compound...
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Halichondrin B was
first isolated from
Halichondria okadai, and
later from the
unrelated sponges Axinella carteri and
Phankella carteri.
Halichondrin...
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simplified synthetic analogue. This was
necessary with the
natural product halichondrin B, its
simplified analogue eribulin now
approved and
marketed as an anticancer...
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Halichondria produces the
eribulin (Halaven)
precursor halichondrin B...
- "Natural
product drug discovery: the
successful optimization of ISP-1 and
halichondrin B".
Current Opinion in
Chemical Biology. 15 (4): 523–528. doi:10.1016/j...
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polyether metabolism. Alternatively, it may be a
bacterial natural product.
Halichondrin B Yeung, Kap-Sun; Paterson, Ian (2005-10-21). "Advances in the Total...
- vivo
anticancer activities of
synthetic macrocyclic ketone analogues of
halichondrin B."
Cancer Res. 61 (3): 1013–21. PMID 11221827.
Zhang HJ, Yi YH, Yang...
