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Telomerase reverse transcriptase (abbreviated to TERT, or
hTERT in humans) is a
catalytic subunit of the
enzyme telomerase, which,
together with the telomerase...
- in
which hTERT can be detected.
Since hTERT expression is
dependent only on the
number of
tumor cells within a sample, the
amount of
hTERT indicates...
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Andrews also co-discovered the
protein component of
human telomerase (
hTERT). The
hTERT gene is
present in all
human cells, but is
repressed in most. In 1997...
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cerebral development. The
deletion of the
telomerase reverse transcriptase (
hTERT) gene
localized in 5p15.33 may
contribute to the
phenotypic changes in cri...
- post-translational
regulatory mechanism include VHL, PML, MDM2, POLD1, RelA, HAND1 and
hTERT,
among many others. It is now
known that long
noncoding RNAs originating...
-
Tollefsbol TO (2012). "Regulation of the
human catalytic subunit of
telomerase (
hTERT)". Gene. 498 (2): 135–46. doi:10.1016/j.gene.2012.01.095. PMC 3312932. PMID 22381618...
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Isotretinoin has been
speculated to down-regulate the
enzyme telomerase and
hTERT,
inhibiting "cellular
immortalization and tumorigenesis." In a 2007 study...
- with G-quadruplex in the
promoter of the
human telomerase (
hTERT) gene and
regulate hTERT expression In 2019, the telomere-binding-factor-2 (TRF2 or TERF2)...
- tumor-specific
promoters like
human telomerase (
hTERT), osteocalcin,
carcinoembryonic antigen; however, only
hTERT promoter was
found to
enter clinic trials...
-
motif D of the
reverse transcriptase domain of the
telomerase protein,
hTERT,
leads to this phenotype. Thus
telomerase dosage is
important for maintaining...
