-
reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase,
official symbol HMGCR) is the rate-controlling
enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent...
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autoimmune disease. Some
specific examples of
autoantibodies are Anti-Jo-1, Anti-
HMGCR, Anti-TIF1, etc.
Treatment for
myositis depends on the
underlying cause...
- Morales-Rosado JA,
Schwab TL, et al. (2023-06-01). "Bi-allelic
variants in
HMGCR cause an autosomal-recessive
progressive limb-girdle
muscular dystrophy"...
- Statin-****ociated
autoimmune myopathy (SAAM), also
known as anti-
HMGCR myopathy, is a very rare form of
muscle damage caused by the
immune system in people...
-
Perez Y, Birk OS (February 2023). "Limb
girdle muscular disease caused by
HMGCR mutation and
statin myopathy treatable with mevalonolactone". Proc Natl...
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following SSD-containing
proteins represent each family: HMG-CoA
reductase (
HMGCR),
involved in the
biosynthesis of cholesterol. This was the
first protein...
- acetyl-CoA
carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA
reductase (
HMGCR), key
enzymes involved in
regulating de novo
biosynthesis of
fatty acid...
- Q8WW32 7124
HMGCL HGNC:5005 P35914 7125 HMGCLL1 HGNC:21359 Q8TB92 7126
HMGCR HGNC:5006 P04035 7127 HMGCS1 HGNC:5007 Q01581 7128 HMGCS2 HGNC:5008 P54868...
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phosphorylates and
inactivates 3-hydroxy-3-methylglutaryl-CoA
reductase (
HMGCR), a key
enzyme in
cholesterol synthesis. HMGR
converts 3-hydroxy-3-methylglutaryl-CoA...
-
directly inhibit the
enzymatic biosynthesis of steroids. HMG-CoA
reductase (
HMGCR) inhibitors, also
known as statins,
prevent the
conversion of HMG-CoATooltip...
