- M4 7.2 84
Human M5 15.7–24 97
Human σ1 287–300 2,000
Guinea pig/rat
hERGTooltip human Ether-à-go-go-Related Gene 3,260 31,600
Human PARP1 1650 ND Human...
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Human α7-nACh 7,900–50,000 IC50
Human α/β/δ/γ-nACh 7,900 IC50
Human hERGTooltip human Ether-à-go-go-Related Gene 34,000–69,000 IC50
Human Notes: (1)...
- 30–260
Human VGSCTooltip Voltage-dependent
sodium channel 48000–86000 Rat
hERGTooltip Human Ether-à-go-go-Related Gene 27100 (IC50Tooltip Half-maximal inhibitory...
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Antagonist VDCCTooltip Voltage-dependent
calcium channel >10,000 ND ND
hERGTooltip Human Ether-à-go-go-Related Gene ND >10,000 (IC50Tooltip Half-maximal...
-
channel 10000+ ND
VGSCTooltip Voltage-gated
sodium channel 5000+ ND
hERGTooltip Human Ether-à-go-go-Related Gene 6013
Blocker Values are Ki (nM). The...
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Human M2 17,000
Human M3 52,500
Human M4 77,600
Human M5 28,200
Human hERGTooltip Human Ether-à-go-go-Related Gene 20,900
Human Values are Ki,
unless otherwise...
- M2 160–230
Human M3 25–52
Human M4 20–82
Human M5 5.6–75
Human hERGTooltip Human Ether-à-go-go-Related Gene 6,500 (IC50Tooltip Half-maximal inhibitory...
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mAChTooltip Muscarinic acetylcholine receptors 37 92 Human/und σ1 546 ND Rat
hERGTooltip Human Ether-à-go-go-Related Gene 130 (IC50Tooltip Half-maximal inhibitory...
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channel >10,000 ND
VGSCTooltip Voltage-gated
sodium channel 2,620 ND
hERGTooltip Human Ether-à-go-go-Related Gene 169
Blocker Values are Ki (nM). The...
- 410–970 ND
Human σ1 332–520 1,990–4,000
Rodent σ2 327–2,100 ≥1,611 Rat
hERGTooltip human Ether-à-go-go-Related Gene 3,400 ND
Human Values are Ki (nM). The...
